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Science 30 December 1966:
Vol. 154. no. 3757, pp. 1675 - 1677
DOI: 10.1126/science.154.3757.1675
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Articles

Immunologic Maturation in utero: Kinetics of the Primary Antibody Response in the Fetal Lamb

Arthur M. Silverstein 1, Charles J. Parshall JR. 1, and Jonathan W. Uhr 2

1 Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2 Irvington House Institute and Department of Medicine, New York University School of Medicine, New York

The kinetics of the primary antibody response to bacteriophage phgrX174 have been studied in the fetal lamnb in utero after permanent indwelling catheterization of the fetal blood vessels. The initial antibody response by the developing fetus to this form of antigenic stimulus is comparable to that found in adult animals and shows none of the characteristics of the immature immunologic response that have generally been ascribed to fetal and neonatal animals.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)