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Science 23 December 1966:
Vol. 154. no. 3756, pp. 1563 - 1566
DOI: 10.1126/science.154.3756.1563
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Articles

Quantitative Immunochemistry and the Evolution of Primate Albumins: Micro-Complement Fixation

Vincent M. Sarich 1 and Allan C. Wilson 2

1 Departments of Anthropology and Biochemistry, University of California, Berkeley
2 Department of Biochemistry, University of California, Berkeley

Quantitative micro-complement fixation was used to compare human serum albumin with the serum albumins of apes, monkeys, and prosimians. The results are consistent with those obtained by other immunological techniques, and they are consistent with the accepted phylogenetic position of these groups. The method requires much less antigen and antibody is more sensitive to small differences in albumin structure. A large scale survey of species differences in protein structure is possible with less than a milliliter of antiserum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Do albumin clocks run on time?.
L Radinsky (1978)
Science 200, 1182-1183
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Albumin phylogeny for clawed frogs (Xenopus).
C. Bisbee, M. Baker, A. Wilson, I Haji-Azimi, and M Fischberg (1977)
Science 195, 785-787
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Convergent Morphological Evolution Detected by Studying Proteins of Tree Frogs in the Hyla eximia Species Group.
L. R. Maxson and A. C. Wilson (1974)
Science 185, 66-68
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Generation Time and Genomic Evolution in Primates.
V. M. Sarich and A. C. Wilson (1973)
Science 179, 1144-1147
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Primate Phylogeny and Immunological Distance.
C. O. Lovejoy, A. H. Burstein, and K. G. Heiple (1972)
Science 176, 803-805
   Abstract »    PDF »
Immunological Detection of Single Amino Acid Substitutions in Alkaline Phosphatase.
G. T. Cocks and A. C. Wilson (1969)
Science 164, 188-189
   Abstract »    PDF »
Phenoxyethanol: Protein Preservative for Taxonomists.
M. Nakanishi, A. C. Wilson, R. A. Nolan, G. C. Gorman, and G. S. Bailey (1969)
Science 163, 681-683
   Abstract »    PDF »
Immunological Time Scale for Hominid Evolution.
V. M. Sarich and A. C. Wilson (1967)
Science 158, 1200-1203
   Abstract »    PDF »
Enzymatic Identification of Fish Products.
A. C. Wilson, G. B. Kitto, and N. O. Kaplan (1967)
Science 157, 82-83
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Science. ISSN 0036-8075 (print), 1095-9203 (online)