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Science 25 November 1966:
Vol. 154. no. 3752, pp. 1053 - 1055
DOI: 10.1126/science.154.3752.1053
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Articles

Vesicular Stomatitis Virus Replication in Human Leukocyte Cultures: Enhancement by Phytohemagglutinin

Robert Edelman 1 and E. Frederick Wheelock 1

1 Departments of Preventive Medicine and Medicine, School of Medicine,Western Reserve University,Cleveland, Ohio 44106

The replication of vesicular stomatitis virus in human leukocyte cultures shows that virus yields can be enhanced 6-to 180-fold by treating the leukocyte cultures with phytohemagglutinin prior to virus inoculation. Data suggest that a substance is produced in phytohemagglutinin-treated leukocyte cultures which is capable, on transfer to fresh leukocytes, of inducing blast cell formation and enhancing virus replication.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies on the Interactions between Viruses and Lymphocytes.
B. R. Bloom, A. Senik, G. Stoner, G. Ju, M. Nowakowski, S. Kano, and L. Jimenez (1977)
Cold Spring Harb Symp Quant Biol 41, 73-83
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Science. ISSN 0036-8075 (print), 1095-9203 (online)