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Science 25 November 1966:
Vol. 154. no. 3752, pp. 1017 - 1019
DOI: 10.1126/science.154.3752.1017
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Articles

Histamine Synthesis in Man: Inhibition by 4-Bromo- 3-Hydroxybenzyloxyamine

Robert J. Levine 1

1 Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Oral administration of 4-bromo-3-hydroxybenzyloxyamine to normal humans resulted in decreased urinary excretion of histamine; the normal increase in urinary levels of histamine after oral histidine loading was prevented. In two patients having systemic mastocytosis, additional evidence of inhibition of biosynthesis of histamine included marked reduction in symptoms attributed to histamine, and prevention of symptomatic exacerbation associated with histidine loading.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Failure of Epinephrine to Provoke Flushing in Patients with Systemic Mastocytosis.
A. B. VAIDYA, K. O. WUSTRACK, and R. J. LEVINE (1971)
Ann Intern Med 74, 711-713
   Abstract »    PDF »
Mast Cell Disease: A Cutaneous Variant With Multisystem Involvement.
C. F. Burgoon Jr., J. H. Graham, and D. L. McCaffree (1968)
Arch Dermatol 98, 590-605
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)