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Science 18 November 1966:
Vol. 154. no. 3751, pp. 899 - 901
DOI: 10.1126/science.154.3751.899
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Articles

Subacute Sclerosing Leukoencephalitis: Ultrastructure of Intranuclear and Intracytoplasmic Inclusions

Isabel Tellez-Nagel 1 and Donald H. Harter 2

1 Departments of Neurology and Neuropathology, Albert Einstein College of Medicine, New York
2 Rockefeller University, New York 10021

Intranuclear inclusions found in glial cells of two cases of subacute sclerosing leukoencephalitis have been examined in the electron microscope. The inclusions are composed of filamentous tubules 170 to 230 angstroms in diameter, which bear a general resemblance to the intranuclear structures observed in cells infected with measles virus. This finding provides further suggestive evidence that a virus may be involved in the pathogenesis of subacute sclerosing leukoencephalitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immune Response-Mediated Protection of Adult but Not Neonatal Mice from Neuron-Restricted Measles Virus Infection and Central Nervous System Disease.
D. M. P. Lawrence, M. M. Vaughn, A. R. Belman, J. S. Cole, and G. F. Rall (1999)
J. Virol. 73, 1795-1801
   Abstract »    Full Text »
Measles virus nucleotide sequences: detection by hybridization in situ.
A. Haase, P Ventura, C. Gibbs Jr, and W. Tourtellotte (1981)
Science 212, 672-675
   Abstract »    PDF »
Ocular Manifestations of Subacute Sclerosing Panencephalitis.
B. Morgan, D. N. Cohen, A. D. Rothner, and R. Williamson (1976)
Arch Pediatr Adolesc Med 130, 1019-1021
   Abstract »    PDF »
Nonviral Intranuclear Filamentous Inclusions.
Cheng-Mei Shaw and S. M. Sumi (1975)
Arch Neurol 32, 428-432
   Abstract »    PDF »
Acute Multiple Sclerosis: Confirmation of "Paramyxovirus-like" Intranuclear Inclusions.
C. S. Raine, J. M. Powers, and K. Suzuki (1974)
Arch Neurol 30, 39-46
   Abstract »    PDF »
Subacute Sclerosing Panencephalitis: Transmission of the Virus to Calves and Lambs.
P. Thein, D. M. Vet, A. Mayr, D. M. Vet, V. t. Meulen, H. Koprowski, M. Y Kackell, D. Muller, and R. Meyermann (1972)
Arch Neurol 27, 540-548
   Abstract »    PDF »
Subacute Sclerosing Panencephalitis (SSPE) A Clinicopathologic Study of the Retinal Lesions.
M. B. Landers III and G. K. Klintworth (1971)
Arch Ophthalmol 86, 156-163
   Abstract »    PDF »
Chronic Polymyositis and Myxovirus-like Inclusions: Electron Microscopic and Viral Studies.
T. Sato, D. L. Walker, H. A. Peters, H. H. Reese, and S.-M. Chou (1971)
Arch Neurol 24, 409-418
   Abstract »    PDF »
Ophthalmic Manifestations of Subacute Sclerosing Panencephalitis.
R. M. Robb and G. V. Watters (1970)
Arch Ophthalmol 83, 426-435
   Abstract »    PDF »
Subacute Sclerosing Panencephalitis: A Multidisciplinary Study of Eight Cases.
J. T. Jabbour, J. H. Garcia, H. Lemmi, J. Ragland, D. A. Duenas, and J. L. Sever (1969)
JAMA 207, 2248-2254
   Abstract »    PDF »


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