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Science 18 November 1966:
Vol. 154. no. 3751, pp. 896 - 897
DOI: 10.1126/science.154.3751.896
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Articles

Nucleohistone Dissociation by Ganglioside Micelles

Miriam H. Meisler 1 and Robert H. Mccluer 1

1 Departments of Physiological Chemistry and Psychiatry, Ohio State University, Columbus

The sialic acid-containing glycosphingolipids known as gangliosides can reverse the heat stabilization of DNA by histones. The ability of pure mono-and disialogangliosides to dissociate reconstituted nucleohistone is directly dependent on their sialic acid content; they are effective in concenitrations above their critical micelle concentration.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)