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Science 11 November 1966:
Vol. 154. no. 3750, pp. 790 - 791
DOI: 10.1126/science.154.3750.790
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Articles

Antigenic Determinants Common to Human Immunoglobulins G and M: Importance of Conformational Antigens

Maxime Seligmann 1, Constantin Miaesco 2, and Gilbert Meshaka 3

1 Laboratory of Immunochemistry, HoÂpital Saint-Louis, Paris 10e France
2 Laboratory of Immunochemistry, HoÂpital Saint-Louis, Paris 10e France;chargéde Recherches of the French National Institute of Health and Medical Research
3 Laboratory of Immunochemistry, HoÂpital Saint-Louis, Paris 10e France;chargéde Researchers of the French National Institute of Health and Medical Research

Antiserums produced against certain isolated human myeloma IgGglobulins and absorbed in order to show only individual antigenic specificity crossreact with certain Waldenstrom IgM-globulins. Some of the common antigenic determinants revealed by these cross-reactions depend on the tertiary and quaternary structure of the IgG and IgM molecules and are independent of their K and L light-chain antigenic types.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antigenicity: Some Molecular Aspects.
M. Sela (1969)
Science 166, 1365-1374
   PDF »
Alpha-Chain Disease: A New Immunoglobulin Abnormality.
M. Seligmann, F. Danon, D. Hurez, E. Mihaesco, and J.-L. Preud'homme (1968)
Science 162, 1396-1397
   Abstract »    PDF »
Antibodies to Sequential and Conformational Determinants.
M. Sela, B. Schechter, I. Schechter, and F. Borek (1967)
Cold Spring Harb Symp Quant Biol 32, 537-545
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)