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Science 11 November 1966:
Vol. 154. no. 3750, pp. 772 - 774
DOI: 10.1126/science.154.3750.772
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Articles

Staphylococcal Alpha-Toxin: Effects on Artificial Lipid Spherules

Gerald Weissmann 1, Grazia Sessa 1, and Alan W. Bernheimer 1

1 Departments of Medicine and Microbiology, New York University School of Medicine, New York

Staphylococcal alpha-toxin induces the release of previously sequestered anions or glucose from artificial phospholipid spherules, an effect abolished by specific antitoxin. Alphatoxin resembles streptolysin S in releasing anions or glucose from spherules prepared without cholesterol, and can be distinguished from the membrane-active polyene amphotericin B, which preferentially disrupts spherules containing cholesterol. It may affect biological structures by a similiar interaction with membrane phospholipids.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Assembly of proteins into membranes.
W Wickner (1980)
Science 210, 861-868
   Abstract »    PDF »
Cytolytic Toxins of Bacterial Origin: The nature and properties of cytolytic proteins are discussed with emphasis on staphylococcal agr-toxin.
A. W. Bernheimer (1968)
Science 159, 847-851
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)