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Science 4 November 1966:
Vol. 154. no. 3749, pp. 655 - 657
DOI: 10.1126/science.154.3749.655
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Articles

Antibody-Forming Cells: Population Patterns after Simultaneous Immunization with Different Isoantigens

R. A. McBride 1 and L. W. Schierman 1

1 Department of Surgery, Mount Sinai Hospital, New York 10029

Spleen cells were obtained from chickens stimulated simultaneously with different erythrocytic antigens, and the proportions producing one and two antibodies were determined by the hemolytic-plaque technique. Most cells from birds immunized with two antigens of the same system (B) appeared to produce only one antibody. In a population of cells from birds immunized with antigens of different systems (A and B), a relatively high proportion of cells produced two antibodies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adjuvant Activity of Erythrocyte Isoantigens.
L. W. Schierman and R. A. Mcbride (1967)
Science 156, 658-659
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The Clonal Selection Hypothesis Evaluated by Grafted Cells Reacting Against their Hosts.
M. Simonsen (1967)
Cold Spring Harb Symp Quant Biol 32, 517-523
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