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Science 28 October 1966:
Vol. 154. no. 3748, pp. 529 - 531
DOI: 10.1126/science.154.3748.529
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Articles

Release of Catecholamines and Specific Protein from Adrenal Glands

Norman Kirshner 1, Harvey J. Sage 1, W. James Smith 1, and Annette G. Kirshner 1

1 Departments of Biochemistry and Pathology, Duke University Medical Center, Durham, North Carolina

Rabbit antiserums directed against a purified protein obtained from the catecholamine storage vesicles of the adrenal medulla of the cow were used to study the mechanism of secretion from the adrenal medulla. During secretion evoked by acetylcholine in isolated perfused adrenal glands, catecholamines and the specific intravesicular protein were released in relative amounts comparable to those present in the intact gland. Thus catecholamines are apparently released from the storage vesicles by a process resembling reverse pinocytosis.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)