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Science 21 October 1966:
Vol. 154. no. 3747, pp. 393 - 395
DOI: 10.1126/science.154.3747.393
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Articles

Protein- Polysaccharide Loss during Endochondral Ossification: Immunochemical Evidence

Albert Hirschman 1 and Dominic D. Dziewiatkowski 2

1 Department of Anatomy, State University of New York Downstate Medical Center, Brooklyn 11203
2 Rockefeller University, New York

Fluorescein labeled antibodies to protein- polysaccharides from rat and calf cartilage were used for the histochemical localization of protein- poly saccharide in epiphyseal cartilage. There was less protein- polysaccharide in the zone of provisional calcification than in the proliferating and maturing zones, and none was demonstrable in the metaphysis. During or just preceding cal cification, protein- polysaccharide or its protein component is lost or drastically altered.


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S. Makihira, W. Yan, H. Murakami, M. Furukawa, T. Kawai, H. Nikawa, E. Yoshida, T. Hamada, Y. Okada, and Y. Kato (2003)
Endocrinology 144, 2480-2488
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Identification of Hyaluronidase Activity in Rabbit Dental Pulp.
N. Sakamoto, T. Nakajima, K. Ikunaga, H. Shidahara, H. Okamoto, and K. Okuda (1981)
Journal of Dental Research 60, 850-854
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