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Science 14 October 1966:
Vol. 154. no. 3746, pp. 285 - 287
DOI: 10.1126/science.154.3746.285
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Articles

Rheumatic-like Cardiac Lesions in Mice

William J. Cromartile 1 and John G. Craddock 1

1 Departments of Bacteriology and Medicine, University of North Carolina School of Medicine, Chapel Hill

A single intraperitoneal injection of a sterile extract of sonically disrupted group A streptococcal cells induced an inflammatory process in the hearts of mice. The cardiac lesions, in terms of their distribution and histological features, are similar to the cardiac lesions of rheumatic fever.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathogenesis of Group A Streptococcal Infections.
M. W. Cunningham (2000)
Clin. Microbiol. Rev. 13, 470-511
   Abstract »    Full Text »    PDF »
Mouse electrocardiography: An interval of thirty years.
X. H.T. Wehrens, S. Kirchhoff, and P. A. Doevendans (2000)
Cardiovasc Res 45, 231-237
   Abstract »    Full Text »    PDF »
Streptococcal Cell Wall-Induced Arthritis: Requirements for IL-4, IL-10, IFN-{gamma}, and Monocyte Chemoattractant Protein-1.
R. C. Schimmer, D. J. Schrier, C. M. Flory, K. D. Laemont, D. Tung, A. L. Metz, H. P. Friedl, M. C. Conroy, J. S. Warren, B. Beck, et al. (1998)
J. Immunol. 160, 1466-1471
   Abstract »    Full Text »    PDF »
Comparative Studies of Mitral Valves in Rheumatic Heart Disease.
P. Chopra, H. D. Tandon, V. Raizada, N. Gopinath, C. Butler, and R. C. Williams Jr (1983)
Arch Intern Med 143, 661-666
   Abstract »    PDF »
A Model for Rheumatic Carditis?.
A. TARANTA (1967)
Ann Intern Med 66, 445-446
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)