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Science 14 October 1966:
Vol. 154. no. 3746, pp. 281 - 283
DOI: 10.1126/science.154.3746.281
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Articles

Gamma-A Cold Agglutinin: Importance of Disulfide Bonds in Activity and Structure

Burton R. Andersen 1

1 Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York

Cleavage of disulfide bonds caused by mild reduction with mercaptoethanol produces a reversible loss of cold agglutinin activity and antigen-binding ability in a gamma-A polymer cold agglutinin. Return of agglutination and antigen-binding ability occur only in those molecules that have not been depolyimerized by reduction. Loss of activity becomes irreversible if reduction is followed immediately by alkylation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Correlation of Abnormal Immunoglobulin With Clinical Features of Myeloma: A Cooperative Study by Acute Leukemia Group B.
(1975)
Arch Intern Med 135, 46-52
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Science. ISSN 0036-8075 (print), 1095-9203 (online)