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Science 30 September 1966:
Vol. 153. no. 3744, pp. 1671 - 1672
DOI: 10.1126/science.153.3744.1671
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Articles

Thyroglobulin: Evidence for Crystallization and Association

W. B. Jakoby 1, L. Labaw 1, H. Edelhoch 1, I. Pastan 1, and J. E. Rall 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

Crystals of thyroglobulin have been obtained from ammonium sulfate solutions and have been examined by electron microscopy as shadowed carbon replicas. Unit size in the crystal is 228 ± 9 angstroms, which corresponds to a molecular weight of 5,300,000. Data are in accord with the possibility that this unit represents a polymer of thyroglobulin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)