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Science 30 September 1966:
Vol. 153. no. 3744, pp. 1666 - 1667
DOI: 10.1126/science.153.3744.1666
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Articles

Antibodies to photoproducts of Deoxyribonucleric Acids Irradiated with Ultraviolet Light

Lawrence Levine 1, Edna Seaman 1, Ellen Hammerschlag 1, and Helen Van Vunakis 1

1 Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts

A rabbit immunized with complexes of methylated bovine serum albumin and ultraviolet-irradiated DNA from calf thymus produced antibodies directed toward the photoproducts in the DNA. Serologic activity appeared after irradiation of DNA at 270 mµ and decreased upon irradiation at 235 mµ. The antigenic determinants of the ultraviolet-treated DNA appear to be photoproducts associated primarily with thymine, as measured by direct dependence of serologic activity on the adenine-thymine content of the DNA, and by inhibition of the Serlolgic reaction by the irradiated di-,tri-,and tetra-(thymidine-5'-phosphate nucleotides.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antinuclear Antibodies and Oral Methoxsalen Photochemotherapy (PUVA) for Psoriasis.
R. S. Stern, W. L. Morison, L. A. Thibodeau, R. A. Kleinerman, J. A. Parrish, D. E. Geer Jr, and T. B. Fitzpatrick (1979)
Arch Dermatol 115, 1320-1324
   Abstract »    PDF »
Photoimmunology.
W. L. Morison, J. A. Parrish, and J. H. Epstein (1979)
Arch Dermatol 115, 350-355
   Abstract »    PDF »
Antibodies to Deoxyribonucleic Acid Irradiated with Ultraviolet Light: Detection by Precipitins and Immunofluorescence.
E. M. Tan (1968)
Science 161, 1353-1354
   Abstract »    PDF »


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