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Science 30 September 1966:
Vol. 153. no. 3744, pp. 1653 - 1654
DOI: 10.1126/science.153.3744.1653
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Articles

Uricolytic Enzymes in Liver of the Dipnoan Protopterus aethiopicus

G. W. Brown Jr. 1, Jesse James 1, Ralph J. Henderson 1, Walter N. Thomas 1, Robert O. Robinson 1, Arthur L. Thompson 1, Earlene Brown 1, and Susan G. Brown 1

1 Department of Biochemistry, University of Texas Medical Branch, Galveston, 77550

The enzymes uricase, allantoinase, and allantoicase have been measured in liver preparations of the African lungfish Protopterus aethiopicus. The levels for these enzymes in lungfish liver suggest that the amount of urea formed in vivo in Protopterus via a uricolytic pathway may be greater than that derived via the Ornithine-urea cycle. The operation of a "purine cycle" in lungfish liver is proposed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell.
B. F. Terjesen, T. D. Chadwick, J. A. J. Verreth, I. Ronnestad, and P. A. Wright (2002)
J. Exp. Biol. 204, 2155-2165
   Abstract »    Full Text »    PDF »
Functional ureogenesis in the gobiid fish Mugilogobius abei.
K Iwata, M Kajimura, and T Sakamoto (2000)
J. Exp. Biol. 203, 3703-3715
   Abstract »    PDF »
Serum Osmolality in the Coelacanth, Latimeria chalumnae: Urea Retention and Ion Regulation.
G. E. Pickford and F. B. Grant (1967)
Science 155, 568-570
   Abstract »    PDF »
Urea and Its Formation in Coelacanth Liver.
G. W. Brown Jr. and S. G. Brown (1967)
Science 155, 570-573
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)