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Science 23 September 1966:
Vol. 153. no. 3743, pp. 1523 - 1525
DOI: 10.1126/science.153.3743.1523
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Articles

Infrared Analysis of Rat Bone: Age Dependency of Amorphous and Crystalline Mineral Fractions

John D. Termine 1 and Aaron S. Posner 1

1 Hospital for Special Surgery, Cornell University Medical College, New York, New York 10021

Quantitative infrared spectrophotometric analysis of whole femurs from male rats demonstrates that anorphous calcium phosphate is a major component of bone mineral. The amount of amorphous calcium phosphate in whole bone decreases while the crystalline bone apatite increases during early stages of bone formation. Mature rat bone contains constant levels of both amorphous and crystalline calcium phosphate.


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