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Science 16 September 1966:
Vol. 153. no. 3742, pp. 1416 - 1417
DOI: 10.1126/science.153.3742.1416
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Articles

Sleep Deprivation and Brain Acetylcholine

Malcolm B. Bowers Jr. 1, Ernest L. Hartmann 2, and Daniel X. Freedman 3

1 Departmitent of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
2 Department of Psychiatry, Tufts University, Medford, Massachusetts
3 Department of Psychiatry, University of Chicago, Chicago, Illinois

Rats deprived of D-state sleep (and, to some extent, of slow-wave sleep) for 96 hours show a significant fall in brain acetylcholine in the telencephalon; there were no significant changes in the diencephalon and brain stem. Restraint stress and activity wheel stress produced no significant change in acetylcholine levels in any of these regions; the telencephalic response to sleep deprivation, therefore, cannot be attributed to nonspecific stress. The effects of D-state deprivation and the psychoactive anticholinergic drugs on telencephalic acetylcholine levels are similar.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Effect of Physostigmine on Normal Human Sleep and Dreaming.
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Seizure Occurrence and Interspike Interval: Telemetered Electroencephalogram Studies.
J. R. Stevens, B. L. Lonsbury, and S. L. Goel (1972)
Arch Neurol 26, 409-419
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Retrograde Amnesia: Electroconvulsive Shock Effects after Termination of Rapid Eye Movement Sleep Deprivation.
W. Fishbein, J. L. McGaugh, and J. R. Swarz (1971)
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Sleep Patterns of the Monkey and Brain Serotonin Concentration: Effect of p-Chlorophenylalanine.
E. D. Weitzman, M. M. Rapport, P. McGregor, and J. Jacoby (1968)
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