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Science 9 September 1966:
Vol. 153. no. 3741, pp. 1267 - 1269
DOI: 10.1126/science.153.3741.1267
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Articles

N-Cyclohexyl Linoleamide: Metabolism and Cholesterol-Lowering Effect in Rats

Hiroshi Nakatani 1, Hideaki Fukushima 1, Atsushi Wakimura 1, and Michio Endo 2

1 Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., Kasugade-cho, Konohana-ku, Osaka, Japan
2 Takarazuka Radiation Laboratory, SumitomoAtomicEnergyIndustriesLtd., Suenari, Kurando, Takarazuka, Japan

More than half of orally administered N-cyclohexyl linoleamide-car-boxyl-C14 yl-CI was recovered from feces of rats, and 30 to 50 percent of the absorbed carbon-14 activity was excreted in urine. N-Cyclohexyl linoleamide had an inhibitory eflect on the absorption of cholesterol from the thoracic duct and caused a decrease in the deposition of cholesterol in the livers of rats that had been fed cholesterol.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)