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Science 9 September 1966:
Vol. 153. no. 3741, pp. 1264 - 1267
DOI: 10.1126/science.153.3741.1264
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Articles

Antiserum to Lymphocytes: Prolonged Survival of Canine Renal Allografts

Anthony P. Monaco 1, William M. Abbott 1, H. Biemann Othersen 1, Richard L. Simmons 1, Mary L. Wood 1, Martin H. Flax 1, and Paul S. Russell 1

1 Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston

A horse immunized with dog lynmphocytes produced an antiserum which agglutinated canine lymphocytes in vitro and caused prolonged lymphopenia in dogs in vivo. Renal transplants in dogs treated with this antiserum survived for long periods, two of the grafts surviving beyond 350 days with normal function and histologic appearance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antiserum to Lymphocytes: Interactions with Chemical Immunosuppressants.
R. L. Simmons, A. J. Ozerkis, and R. J. Hoehn (1968)
Science 160, 1127-1130
   Abstract »    PDF »
Antilymphocyte Serum as an Immunosuppressive Agent.
P. S. RUSSELL (1968)
Ann Intern Med 68, 483-486
   Abstract »    PDF »
Heterologous Antilymphocyte Globulin: Studies in vitro.
L. J. Humphrey, H. M. Kauffman Jr., and E. Dunn (1967)
Science 157, 441
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)