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Science 19 August 1966:
Vol. 153. no. 3738, pp. 887 - 888
DOI: 10.1126/science.153.3738.887

Articles

Antibody Formation in Nonimmune Mouse Peritoneal Cells after Incubation in Gum Containing Antigen

A. E. Bussard 1

1 Department of Cellular Immunology, Institut Pasteur, Paris, France

Peritoneal cells from normal mice in a semisolid medium containing sheep erythrocytes were incubated at 37°C for 2 or 3 days. During this period, hemolytic antibodies developed spontaneously. Arguments are presented that true de novo synthesis of antibody has taken place in previously uncommitted cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Primary Antibody Response Induced in vitro Among Cells from Normal Animals.
A. E. Bussard (1967)
Cold Spring Harb Symp Quant Biol 32, 465-475
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Science. ISSN 0036-8075 (print), 1095-9203 (online)