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Articles
Antibody Formation in Nonimmune Mouse Peritoneal Cells after Incubation in Gum Containing Antigen
1 Department of Cellular Immunology, Institut Pasteur, Paris, France
Peritoneal cells from normal mice in a semisolid medium containing sheep erythrocytes were incubated at 37°C for 2 or 3 days. During this period, hemolytic antibodies developed spontaneously. Arguments are presented that true de novo synthesis of antibody has taken place in previously uncommitted cells.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)