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Science 12 August 1966:
Vol. 153. no. 3737, pp. 765 - 767
DOI: 10.1126/science.153.3737.765
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Articles

Tetrodotoxin Does Not Block Excitation from Inside the Nerve Membrane

Toshio Narahashi 1, Nels C. Anderson 1, and John W. Moore 1

1 Department of Physiology, Duke University Medical Center, Durham, North Carolina 27706

Tetrodotoxin does not block the action potential or membrane sodium current when internally perfused through the giant axon of a squid at much higher concentrations than those required for blocking by external application. It is suggested that the gate for the sodium channel is located on the exterior surface of the axon, because tetrodotoxin is not lipid soluble.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future.
T. Narahashi (2000)
J. Pharmacol. Exp. Ther. 294, 1-26
   Abstract »    Full Text »
Saxitoxin and Tetrodotoxin: Comparison of Nerve Blocking Mechanism.
T. Narahashi, H. G. Haas, and E. F. Therrien (1967)
Science 157, 1441-1442
   Abstract »    PDF »
Potency Difference between the Zwitterion Form and the Cation Forms of Tetrodotoxin.
G. Camougis, B. H. Takman, J. Rene, and P. Tasse (1967)
Science 156, 1625-1627
   Abstract »    PDF »
Tetrodotoxin Derivatives: Chemical Structure and Blockage of Nerve Membrane Conductance.
T. Narahashi, J. W. Moore, and R. N. Poston (1967)
Science 156, 976-979
   Abstract »    PDF »
Effects of Tetrodotoxin on Excitability of Squid Giant Axons in Sodium-Free Media.
A. Watanabe, I. Tasaki, I. Singer, and L. Lerman (1967)
Science 155, 95-97
   Abstract »    PDF »


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