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Science 5 August 1966:
Vol. 153. no. 3736, pp. 647 - 649
DOI: 10.1126/science.153.3736.647
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Articles

Subclasses of Human Immunoglobulin A Based on Differences in the Alpha Polypeptide Chains

Jean-Pierre Vaerman 1 and Joseph F. Heremans 1

1 Research Department of Internal Pathology, Cliniques Universitaires Saint-Pierre, Louvain, Belgium

Antiserum from goats immunized with heavy polypeptide chains from a ggrA-type myeloma globulin was absorbed with serum from patients with selective absence of immunoglobulin A (ggrA). The resulting reagents could be used for the classification of 58 ggrA-myeloma proteins into two distinct antigenic types, respectively called subclasses He and Le. These differences were shown to be related to the heavy (alpha) polypeptide chains and independent of the integrity of interchain disulfide bridges. The ggrA-immunoglobulin from normal serum appears to consist, for the most part, of molecules with Le subclass specificity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alpha-Chain Disease: A New Immunoglobulin Abnormality.
M. Seligmann, F. Danon, D. Hurez, E. Mihaesco, and J.-L. Preud'homme (1968)
Science 162, 1396-1397
   Abstract »    PDF »
Carboxy-Terminal Amino Acids of gammaA and gammaM Heavy Chains.
C. A. Abel and H. M. Grey (1967)
Science 156, 1609-1610
   Abstract »    PDF »
Antigenic Heterogeneity of Human Immunoglobulin A Proteins.
W. D. Terry and M. S. Roberts (1966)
Science 153, 1007-1008
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)