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Science 5 August 1966:
Vol. 153. no. 3736, pp. 643 - 644
DOI: 10.1126/science.153.3736.643
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Articles

Hemopoietic Colony-Forming Units in Regenerating Mouse Liver: Suppression by Anticoagulants

Myron L. Varon 1 and Leonard J. Cole 1

1 U.S. Naval Radiological Defense Laboratory, San Francisco, California

After hepatic injury induced by carbon tetrachloride, mitotically active hematopoietic cells of nonhepatic origin localize in the liver as judged by an increase in colony-forming nodules in the spleens of lethally irradiated recipient mice on intravenous injection of cells from these livers. The administration of warfarin suppresses the localization of colony-forming units in the regenerating liver by inhibiting the coagulation mechanism of the donor animals.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)