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Science 29 July 1966:
Vol. 153. no. 3735, pp. 547 - 548
DOI: 10.1126/science.153.3735.547
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Articles

Hepatic Synthesis of Alpha2 (Acute Phase)-Globulin of Rat Plasma

Edward J. Sarcione 1 and Arthur E. Bogden 2

1 Department of Medicine, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York 14203
2 Mason Research Institute, 20 Howard Street, Worcester, Massachusetts 01608

Synthesis of plasma alpha2 (acute phase)-globulin was demonstrated in isolated perfused rat liver obtained from animals showing acute inflammatory reaction to injury. These findings indicate that the liver is a source of the globulin and that appearance of this protein in the serum results from de novo synthesis by the liver rather than from release of performed and stored globulin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)