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Science 15 July 1966:
Vol. 153. no. 3733, pp. 315 - 316
DOI: 10.1126/science.153.3733.315
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Articles

Inhibition of Protein Synthesis: A Mechanism for the Production of Impaired Iron Absorption

Norton J. Greenberger 1 and Richard D. Ruppert 1

1 Department of Medicine, Ohio State University Hospital, Columbus

Treatment of rats with cycloheximide results in a defect in intestinal iron transport. A similar defect occurs after the parenteral administration of iron. Under both conditions there is impaired uptake of iron into the mucosal cells as well as defective transfer from the intestinal mucosa. It is suggested that the interference in iron transport may be due to a deficiency of an unidenti-fild carrier Substance.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)