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Science 15 July 1966:
Vol. 153. no. 3733, pp. 308 - 310
DOI: 10.1126/science.153.3733.308
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Articles

Electron-Microscopic Autoradiography of Rat Hypothalamus after Intraventricular H3-Norepinephrine

G. K. Aghajanian 1 and F. E. Bloom 1

1 Departments of Psychiatry and Anatomy, Yale University, New Haven, Connecticut

Tritiated norepinephrine was injected into the lateral ventricles of rats, and its localization in the hypothalamus was determined by light and electron-microscopic autoradiography. Eighty percent of the autoradiographic grains were located over nerve endings and unmyelinated axons. Large, dense synaptic vesicles were present in most of the endings and axons with activity. Grains were rarely seen over myelinated axons, glia, or blood vessels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytochemistry of Synapses: Selective Staining for Electron Microscopy.
F. E. Bloom and G. K. Aghajanian (1966)
Science 154, 1575-1577
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Science. ISSN 0036-8075 (print), 1095-9203 (online)