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Science 1 July 1966:
Vol. 153. no. 3731, pp. 75 - 76
DOI: 10.1126/science.153.3731.75
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Articles

Antiserum to Immunoglobulin A: Inhibition of Cell-Mediated Demyelination in Tissue Culture

G. F. Winkler 1 and B. G. Arnason 1

1 Department of Neurology and Joseph P. Kennedy Jr. Memorial Laboratories, Massachusetts General Hospital, and Harvard Medical School Boston, Massachusetts

Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)