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Science 24 June 1966:
Vol. 152. no. 3730, pp. 1766 - 1768
DOI: 10.1126/science.152.3730.1766
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Articles

Neurological Defect: Manganese in Phenocopy and Prevention of a Genetic Abnormality of Inner Ear

Lawrence Erway 1, Lucille S. Hurley 1, and Alex Fraser 1

1 Departments of Genetics and Nutrition, University of California, Davis 95616

A specific congenital ataxia may be caused by presence of mutant genes and by manganese deficiency during prenatal development in normal mice. Supplementation of the diet of mutant mice with manganese during prenatal development rectifies the aberrant development, resulting in normal behavior. The congential ataxa results from defective development of the the otoliths.


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