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Science 24 June 1966:
Vol. 152. no. 3730, pp. 1764 - 1765
DOI: 10.1126/science.152.3730.1764
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Articles

Reserpine: Inhibition of Olfactory Blockage of Pregnancy in Mice

C. J. Dominic 1

1 Physiological Laboratory, University of Cambridge, Cambridge, England

Failure of pregnancy in newly mated female mice exposed to fresh urine from alien males is prevented by administration of reserpine, at 6.25 micrograms per day per female, on days 1 to 5 post coitum-that is, throughout the period of exposure to male urine and for 2 more days. Since reserpine is known to suppress the inhibitory center in the hypothalamus controlling the release of prolactin, inhibition by reserpine of the blockage of pregnancy provides a strong direct indication of hypothalamic mediation in the male-induced failure of pregnancy in mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reserpine and Hypothalamic Mediation.
B. L. Welch, H. G. Langford, and C. J. Dominic (1967)
Science 155, 851-852
   PDF »
Galactorrhea and Abnormal Menses Associated With a Long-Acting Progesterone.
R. J. Bolognese, M. S. Piver, and J. D. Feldman (1967)
JAMA 199, 42-43
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)