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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1397 - 1398
DOI: 10.1126/science.152.3727.1397
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Articles

Transmigration of Lymph Nodes by Tumor Cells

Bernard Fisher 1 and Edwin R. Fisher 1

1 Departments of Surgery and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

When either V2, Brown-Pearce, or Walker tumor cells were perfused at low pressure into the afferent lymphatic of popliteal lymph nodes or were injected into the foot pads of rabbits, they rapidly appeared in lymph draining from the node. This finding indicates that lymph nodes are not the effective barrier to dissemination of tumor cells they had previously been assumed to be.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biological Research in the Evolution of Cancer Surgery: A Personal Perspective.
B. Fisher (2008)
Cancer Res. 68, 10007-10020
   Abstract »    Full Text »    PDF »
Regional Lymph Node Metastases; a Singular Manifestation of the Process of Clinical Metastases in Cancer: Contemporary Animal Research and Clinical Reports Suggest Unifying Concepts.
B. Cady (2007)
Ann. Surg. Oncol. 14, 1790-1800
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)