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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1386 - 1388
DOI: 10.1126/science.152.3727.1386
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Articles

Puromycin Analogs: Action of Adrenocorticotropic Hormone and the Role of Glycogen

Leonard D. Garren 1, Warren W. Davis 1, R. Michael Crocco 1, and Robert L. Ney 2

1 National Institutes of Health, Bethesda, Maryland
2 Vanderbilt University Medical School, Nashville, Tennessee

The effect of the injection into rats of analogs of puromycin, 6-dimethylaminopurine, and the aminonucleoside of puromycin on the stimullation of steroidogenesis by adrenocorticotropic hormone was coin pared with that of puromycin and cycloheximide. This stimulation was blocked only by the antibiotics, which also inhibited adrenal protein synthesis. Glycogenolysis is not associated with the primary mechanism of the adrenocorticotropic hormone stimnulation of steroid hormone biosynthesis in rats.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)