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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1375 - 1376
DOI: 10.1126/science.152.3727.1375
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Articles

Protective Action of Polycyclic Hydrocarbons against Induction of Adrenal Necrosis by Dimethylbenzanthracene

P. H. Jellinck 1 and Barbara Goudy 1

1 Cancer Research Centre, University of British Colunmbia, Vancouver, Canada

Treatment of rats with certain polycyclic hydrocarbons shifts the hydroxylation of dimethylbenzanthracene (DMBA) by liver microsomes from the side-chain to the ring. Protection by these hydrocarbons against dimethylbenzanthracene-induced adrenal necrosis is possibly achieved by decreasing the yield of the 7-hydroxymethyl derivative of dimethylbenzanthracene which may act as the necrotic agent by virtue of its strutctural resemblance to the adrenocortical steroids.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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A. H. Conney (2003)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)