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Science 27 May 1966:
Vol. 152. no. 3726, pp. 1274 - 1276
DOI: 10.1126/science.152.3726.1274

Articles

Effect of Interferon on Early Interferon Production

Hilton B. Levy 1, Charles E. Buckler 1, and Samuel Baron 1

1 Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)