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Science 27 May 1966:
Vol. 152. no. 3726, pp. 1257 - 1259
DOI: 10.1126/science.152.3726.1257
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Articles

Natural Human Antibodies to Gram-Negative Bacteria: Immunoglobulins G, A, and M

Irun R. Cohen 1 and Leslie C. Norins 1

1 Venereal Disease Research Laboratory, Comnmunicable Disease Center, Atlanta, Georgia 30333

Significant amounts of immunoglobulins G and M, and a small amount of natural antibodies reactive with Neisseria gonorrhoeae and Escherichia coli, have been detected in human adult serums by imnmunofluorescent techniques. Umbilical cord serums also contained substantial immunoglobulin-G antibody but little or no M or A. These findings challenge the concept that natural antibodies reactive with Gram-negative bacteria are primarily of the immunoglobulin-M class.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa.
A. D. Redd, D. Dabitao, J. H. Bream, B. Charvat, O. Laeyendecker, N. Kiwanuka, T. Lutalo, G. Kigozi, A. A. R. Tobian, J. Gamiel, et al. (2009)
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   Abstract »    Full Text »    PDF »
Limited Periods of Gene Expression in Immunoglobulin-Synthesizing Cells.
D. N. Buell and J. L. Fahey (1969)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)