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Science 27 May 1966:
Vol. 152. no. 3726, pp. 1248 - 1250
DOI: 10.1126/science.152.3726.1248
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Articles

Inhibition of Insulin Release by Norepinephrine in Man

Daniel Porte Jr. 1 and Robert H. Williams 1

1 Department of Medicine, University of Washington School of Medicine, Seattle

Normal subjects were given glucose (300 mg/ min) or tolbutamide (1 g, intravenously), alone and during intravenous infusions of norepi-nephrine (6 lg/ min). Immunoreactive insulin concentration was less than expected during the infusions of norepinephrine, but returned to higher values after the norepinephrine infusions. From these data it is concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)