Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 May 1966:
Vol. 152. no. 3726, pp. 1248 - 1250
DOI: 10.1126/science.152.3726.1248
Prev | Table of Contents | Next

Articles

Inhibition of Insulin Release by Norepinephrine in Man

Daniel Porte Jr. 1 and Robert H. Williams 1

1 Department of Medicine, University of Washington School of Medicine, Seattle

Normal subjects were given glucose (300 mg/ min) or tolbutamide (1 g, intravenously), alone and during intravenous infusions of norepi-nephrine (6 lg/ min). Immunoreactive insulin concentration was less than expected during the infusions of norepinephrine, but returned to higher values after the norepinephrine infusions. From these data it is concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains.
E. D. Berglund, C. Y. Li, G. Poffenberger, J. E. Ayala, P. T. Fueger, S. E. Willis, M. M. Jewell, A. C. Powers, and D. H. Wasserman (2008)
Diabetes 57, 1790-1799
   Abstract »    Full Text »    PDF »
Tyramine-Mediated Activation of Sympathetic Nerves Inhibits Insulin Secretion in Humans.
L. K. Gilliam, J. P. Palmer, and G. J. Taborsky Jr. (2007)
J. Clin. Endocrinol. Metab. 92, 4035-4038
   Abstract »    Full Text »    PDF »
Immunohistochemical Localization of Monoamine Oxidase Type B in Pancreatic Islets of the Rat.
Y.-H. Huang, A. Ito, and R. Arai (2005)
J. Histochem. Cytochem. 53, 1149-1158
   Abstract »    Full Text »    PDF »
Improvement of Insulin Sensitivity after Adrenalectomy in Patients with Pheochromocytoma.
T. D. Wiesner, M. Bluher, M. Windgassen, and R. Paschke (2003)
J. Clin. Endocrinol. Metab. 88, 3632-3636
   Abstract »    Full Text »    PDF »
Glucose Sensing in Pancreatic {beta}-Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus.
F. C. Schuit, P. Huypens, H. Heimberg, and D. G. Pipeleers (2001)
Diabetes 50, 1-11
   Abstract »    Full Text »
Differences in adrenergic recognition by pancreatic A and B cells.
F. Schuit and D. Pipeleers (1986)
Science 232, 875-877
   Abstract »    PDF »
The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation.
R. DiRocco and H. Grill (1979)
Science 204, 1112-1114
   Abstract »    PDF »
The Metabolic Effects of Excess Noradrenaline Secretion From a Pheochromocytoma.
J. Passwell, H. Boichis, D. Lotan, R. David, R. Theodor, B. E. Cohen, and M. Many (1977)
Arch Pediatr Adolesc Med 131, 1011-1014
   Abstract »    PDF »
Hyperinsulinemic Hypoglycemia Associated With a Neurofibrosarcoma.
S. S. Lyall, N. J. Marieb, J. K. Wise, J. L. Cornog, E. C. Neville, and P. Felig (1975)
Arch Intern Med 135, 865-867
   Abstract »    PDF »
Disordered Glucose and Insulin Metabolism in Patients With Insulinoma.
S.-W. Shen (1975)
Arch Intern Med 135, 668-672
   Abstract »    PDF »
Hypoinsulinemia of Hypothyroidism.
J. H. Shah and G. M. Cerchio (1973)
Arch Intern Med 132, 657-661
   Abstract »    PDF »
Carbohydrate Metabolism in Mania: Before and After Lithium Carbonate Treatment.
G. R. Heninger and P. S. Mueller (1970)
Arch Gen Psychiatry 23, 310-319
   Abstract »    PDF »
Inhibition of Insulin Secretion by Catecholamines in Pheochromocytoma.
J. A. COLWELL (1969)
Ann Intern Med 71, 251-256
   Abstract »    PDF »
Sympathetic Regulation of Insulin Secretion: Its Relation to Diabetes Mellitus.
D. Porte Jr. (1969)
Arch Intern Med 123, 252-260
   Abstract »    PDF »
Role of Free Fatty Acids in Glucose Homeostasis.
N. B. Ruderman, C. J. Toews, and E. Shafrir (1969)
Arch Intern Med 123, 299-313
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)