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Science 20 May 1966:
Vol. 152. no. 3725, pp. 1074 - 1075
DOI: 10.1126/science.152.3725.1074
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Articles

Murine Leukemia Viruses: Antigenic Studies by Quantitative Complement Fixation

Paul Gerber 1, Timothy E. O'Connor 1, and Suzette M. Birch 1

1 Division of Biologic Standards and National Cancer Institute, National Institutes of Health, Bethesda, Maryland

The murine leukemia viruses of Rauscher and Friend, derived from plasnma of infected Balb/c mice, was purified. Their antigenic relationship was studied by quantitative complement-fixation reactions with the virion antigen and homologous antiserums. The complement-fixation curves observed in cross-reactions indicated close antigenic similarity between these two leukemia viruses. Highly purified viral preparations contained detectable amounts of host antigens.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)