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Science 20 May 1966:
Vol. 152. no. 3725, pp. 1069 - 1071
DOI: 10.1126/science.152.3725.1069
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Articles

Stable Complex of Fibrinogen and Fibrin

Takeru Sasaki 1, Irvine H. Page 1, and John R. Shainoff 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio 44106

Fibrin-stabilizing factor acts on monomeric fibrin combined with fibrinogen to form a stable complex that is soluble at physiologic pH and ionic strength. The complex has been isolated by chromatography on agarose gel and characterized by sedimentation rate near 24 Sw.20 at both pH 5.3 and 7.4, by coagulability when treated with thrombin, and by content of fibrinopeptides. Formation of the complex could provide a pathway for solubilization of monomeric fibrin produced in circulating blood.


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