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Science 6 May 1966:
Vol. 152. no. 3723, pp. 776 - 778
DOI: 10.1126/science.152.3723.776
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Articles

Homocystinuria: Excretion of a New Sulfur-Containing Amino Acid in Urine

Thomas L. Perry 1, Shirley Hansen 1, Hans-Peter Bar 1, and Lynne MacDougall 1

1 Department of Pharmacology, University of British Columbia, Vancouver 8, Canada

An unusual homocysteine-containing compound, 5-amino-4-imidazolecarboxamide-5'-S-homocysteinylriboside, was isolated from the urine of a child with homocystinuria and detected in the urines of six homocystinurics. Its metabolic origin is not clear, and the data suggest the existence in man of now unknown alternate pathways for the metabolism of methionine and of purines.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Homolanthionine Excretion in Homocystinuria.
T. L. Perry, S. Hansen, and L. MacDougall (1966)
Science 152, 1750-1752
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)