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Science 29 April 1966:
Vol. 152. no. 3722, pp. 650 - 651
DOI: 10.1126/science.152.3722.650
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Articles

Prolonged Immunosuppression and Tumor Induction by a Chemical Carcinogen Injected at Birth

J. K. Ball 1, N. R. Sinclair 1, and J. A. McCarter 1

1 Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia

The injection of 60 micrograms of 9,10-dimethyl-1,2-benzanthracene into newborn mice gave rise to a very high incidence of malignant thymomas. The tumor incidence was directly related to the dose of the carcinogen. The neonatal injection of the carcinogen also resulted in a depression in the immune response when the animals were challenged with an antigert as early as 4 weeks or as late as 11 weeks after administration of the carcinogen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DMBA and Immunosuppression in the Syrian Golden Hamster.
A.R. Gould (1976)
Journal of Dental Research 55, D98-D102
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Metastasizing Mammary Carcinomas in Rats: Induction and Study of Their Immunogenicity.
U. Kim (1970)
Science 167, 72-74
   Abstract »    PDF »
Carcinogen-Induced Immune Depression: Absence in Mice Resistant to Chemical Oncogenesis.
O. Stutman (1969)
Science 166, 620-621
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)