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Science 22 April 1966:
Vol. 152. no. 3721, pp. 519 - 521
DOI: 10.1126/science.152.3721.519
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Articles

Radiosensitization of X Chromosome of Chinese Hamster Cells Related to Incorporation of 5-Bromodeoxyuridine

W. C. Dewey 1, B. A. Sedita 1, and R. M. Humphrey 1

1 Department of Physics, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston

Selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the X chromosome of Chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. Radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)