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Science 15 April 1966:
Vol. 152. no. 3720, pp. 367 - 370
DOI: 10.1126/science.152.3720.367
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Articles

Erythropoietin: Hypothesis of Action Tested by Analog Computer

A. L. Kretchmar 1

1 Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee

The action of erythropoietin on the pool of undifferentiated bone marrow cells has been examined with the aid of a model tested with an analog computer. The model is consistent with reported experimental results. The essential aspects of the action are (i) the effect is exerted during the S phase of the cell's cycle; (ii) " effective " erythropoietin is present in the cell only during G1 and part of S; and, (iii) hormone molecules survive in the cell for only a limited time in effective form and require a certain time to assume this form.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models.
C. Haurie, D. C. Dale, and M. C. Mackey (1998)
Blood 92, 2629-2640
   Abstract »    Full Text »    PDF »
Simultaneous effects of erythropoietin and colony-stimulating factor on bone marrow cells.
G Van Zant and E Goldwasser (1977)
Science 198, 733-735
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)