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Science 15 April 1966:
Vol. 152. no. 3720, pp. 349 - 352
DOI: 10.1126/science.152.3720.349
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Articles

Chimeric Mice with Donor-Type Liver Cells

Richard C. Hard Jr. 1 and Birgitta Kullgren 2

1 Pediatric Research Laboratories, Variety Club Heart Hospital, and Department of Physiology, University of Minnesota, Minneapolis
2 Department of Histology, Uppsala University, Uppsala, Sweden

C3H mice, made chimeric by lethal x-irradiation followed by injection of (C3H x T6)F1 spleen cells, were later stimulated by CCl4 to produce a vigorous burst of hepatic parenchymal cell mitoses. Cytogenetic studies of the regenerating livers of 11 chimeras identified 89 percent of the cells as donor type by the presence of the distinctive T6 marker.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemopoietic Colony-Forming Units in Regenerating Mouse Liver: Suppression by Anticoagulants.
M. L. Varon and L. J. Cole (1966)
Science 153, 643-644
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Science. ISSN 0036-8075 (print), 1095-9203 (online)