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Science 1 April 1966:
Vol. 152. no. 3718, pp. 85 - 87
DOI: 10.1126/science.152.3718.85
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Articles

Lithium's Failure to Replace Sodium in Mammalian Sympathetic Ganglia

Achilles J. Pappano 1 and Robert L. Volle 1

1 Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Ganglionic responses to electrical stimulation, acetylcholine, and potassium ions were studied in superior cervical ganglia of. cats perfused with media containing lithium chloride instead of sodium chloride. In lithium-Locke, ganglionic transmission and depolarization evoked by acetylcholine were blocked completely but reversibly, while the depolarization produced by potassium ions was unaltered.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biochemical Aspects of Lithium in Affective Disorders.
S. R. Platman and R. R. Fieve (1968)
Arch Gen Psychiatry 19, 659-663
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Crayfish Muscle Fiber: Ionic Requirements for Depolarizing Synaptic Electrogenesis.
M. Ozeki and H. Grundfest (1967)
Science 155, 478-481
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)