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Science 1 April 1966:
Vol. 152. no. 3718, pp. 100 - 102
DOI: 10.1126/science.152.3718.100
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Articles

Pentylenetetrazol Enhances Memory Function

Samuel Irwin 1 and Ali Benuazizi 1

1 Department of Pharmacology, Schering Corporation, Bloomfield, New Jersey

Pentylenetetrazol, in oral doses of 1 to 30 milligrams per kilogram of body weight, significantly facilitated one-trial learning and memory retention in CF1 mice, whether administered before or immediately after the initial trial. The effects appeared significantly greater than those observed in earlier studies with oral administration of strychnine or picrotoxin at 0.2 to 0.8 and 2.4 milligrams per kilogram, respectively.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Strychnine and the Inhibition of Previous Performance.
J. J. Franchina and M. H. Moore (1968)
Science 160, 903-904
   Abstract »    PDF »
Time-Dependent Processes in Memory Storage.
J. L. McGaugh (1966)
Science 153, 1351-1358
   Abstract »    PDF »


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