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Science 25 March 1966:
Vol. 151. no. 3717, pp. 1544 - 1545
DOI: 10.1126/science.151.3717.1544
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Articles

Tetraethylammonium and Tetrodotoxin: Effects on Cochlear Potentials

Y. Katsuki 1, K. Yanagisawa 1, and J. Kanzaki 2

1 Department of Physiology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo
2 Department of Otolaryngology, Keio University Medical School, Shinanomachi, Shinjuku-ku, Tokyo

Tetraethylammonium chloride, which is believed to decrease potassium conductance, and tetrodotoxin, which apparently decreases sodium conductance in nerve fibers, were introduced iontophoretically into the organ of Corti or the scala media of guinea pig cochlea. The former depressed the direct-current endocochlear potential and also the alternating-current cochlear microphonics (the receptor potential of the ear), but tetrodotoxin was ineffective except on the nerve impulses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tetrodotoxin Blocks a Graded Sensory Response in the Eye of Limulus.
R. M. Benolken and C. J. Russell (1967)
Science 155, 1576-1577
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Science. ISSN 0036-8075 (print), 1095-9203 (online)