Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 25 March 1966:
Vol. 151. no. 3717, pp. 1539 - 1541
DOI: 10.1126/science.151.3717.1539
Prev | Table of Contents | Next

Articles

Aflatoxin B1: Binding to DNA in vitro and Alteration of RNA Metabolism in vivo

Michael B. Sporn 1, C. Wesley Dingman 1, Harriette Longacre Phelps 1, and Gerald N. Wogan 2

1 National Cancer Institute, Bethesda, Maryland 20014
2 Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge

Aflatoxin B1 binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B1 may be direct results of the affinity of this agent for DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Advances in Chemical Carcinogenesis: A Historical Review and Prospective.
L. A. Loeb and C. C. Harris (2008)
Cancer Res. 68, 6863-6872
   Full Text »    PDF »
Effects of Prenatal Aflatoxin B1 Exposure on Behaviors of Rat Offspring.
T. Kihara, T. Matsuo, M. Sakamoto, Y. Yasuda, Y. Yamamoto, and T. Tanimura (2000)
Toxicol. Sci. 53, 392-399
   Abstract »    Full Text »    PDF »
Rapid and Marked Inhibition of Rat-Liver RNA Polymerase by Aflatoxin B1.
H. V. Gelboin, J. S. Wortham, R. G. Wilson, M. Friedman, and G. N. Wogan (1966)
Science 154, 1205-1206
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)