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Science 18 March 1966:
Vol. 151. no. 3716, pp. 1392 - 1394
DOI: 10.1126/science.151.3716.1392
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Articles

Internally Perfused Axons: Effects of Two Different Anions on Ionic Conductance

W. J. Adelman Jr. 1, F. M. Dyro 1, and J. P. Senft 1

1 Department of Physiology, University of Maryland School of Medicine, Baltimore, and Marine Biological Laboratory, Woods Hole, Massachusetts

Voltage-clamizped giant axons of squid, internally perfused with potassiumt chloride solutions, showed reduced initial transient memnbrane conductance to voltage and increased overall (leakage) conductance. Unclamtped axons showed reduced action and resting potentials. Ionic conductances and memtbrane potentials were maintained or restored by perfusion with potassiuwn fluoride solutions. As much as 90 percent of internal fluoride could be replaced with chloride without alterationt of normal properties of membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High Intracellular Cl- Concentrations Depress G-Protein-Modulated Ionic Conductances.
R. A. Lenz, T. A. Pitler, and B. E. Alger (1997)
J. Neurosci. 17, 6133-6141
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Science. ISSN 0036-8075 (print), 1095-9203 (online)