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Science 18 February 1966:
Vol. 151. no. 3712, pp. 828 - 830
DOI: 10.1126/science.151.3712.828
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Articles

Rh Factor: Prevention of Isoimmunization and Clinical Trial on Mothers

Vincent J. Freda 1, John G. Gorman 1, and William Pollack 2

1 Departments of Obstetrics and Gynecology and Pathology, Columbia University, New York
2 Ortho Research Foundation, Raritan, New Jersey

The results on the use of ggrG-immunoglobulin to Rh factor for the prevention of active immunization of Rh-negative mothers at risk appear most promising. One hundred and seven mothers in the clinical trial have been followed for periods of about 6 months to 1frac1212 years after delivery. Of these, 48 were treated mothers who received 5 ml ggrG-immunoglobulin to Rh, and 59 were untreated mothers. Of the 48 treated mothers none are actively immunized; seven of the 59 control mothers have become actively immunized to Rh.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Replacement Transfusion as a Treatment of Erythroblastosis Fetalis, by Louis K. Diamond, MD, Pediatrics, 1948;2:520-524.
H. A. Pearson (1998)
Pediatrics 102, 203-205
   Abstract »    Full Text »
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
   Abstract »    PDF »
Prevention of Rh Isoimmunization.
(1968)
Clinical Pediatrics 7, 643-644
   PDF »
Hypersensitivity: Specific Immunologic Suppression of the Delayed Type.
M. Axelrad and D. A. Rowley (1968)
Science 160, 1465-1467
   Abstract »    PDF »
Prevention of Rh Isoimmunization: Progress Report of the Clinical Trial in Mothers.
V. J. Freda, J. G. Gorman, W. Pollack, J. G. Robertson, E. R. Jennings, and J. F. Sullivan (1967)
JAMA 199, 390-394
   Abstract »    PDF »


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