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Science 11 February 1966:
Vol. 151. no. 3711, pp. 702 - 703
DOI: 10.1126/science.151.3711.702
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Articles

Magnesium Pemoline: Enhancement of Brain RNA Polymerases

Alvin J. Glasky 1 and Lionel N. Simon 2

1 Department of Pharmacology, Abbott Laboratories, North Chocago, Illinois
2 Research Department, Illinois State Pediatric Institute, Chicago

The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pemoline Levels in Brain: Enhancement by Dimethyl Sulfoxide.
J. J. Brink and D. G. Stein (1967)
Science 158, 1479-1480
   Abstract »    PDF »
Molecular Biology Among the Neurosciences.
F. O. Schmitt (1967)
Arch Neurol 17, 561-572
   Abstract »    PDF »
Pemoline and Magnesium Hydroxide: Lack of Effect on RNA and Protein Synthesis.
H. H. Stein and T. O. Yellin (1967)
Science 157, 96-97
   Abstract »    PDF »
Magnesium Pemoline: Effect on Avoidance Conditioning in Rats.
P. W. Frey and V. J. Polidora (1967)
Science 155, 1281-1282
   Abstract »    PDF »
Magnesium Pemoline: Failure To Affect in vivo Synthesis of Brain RNA.
N. R. Morris, G. K. Aghajanian, and F. E. Bloom (1967)
Science 155, 1125-1126
   Abstract »    PDF »
Effects of Magnesium Pemoline and Dextroamphetamine on Human Learning.
J. T. Burns, R. F. House, F. C. Fensch, and J. G. Miller (1967)
Science 155, 849-851
   Abstract »    PDF »
Activity and Responsivity in Rats after Magnesium Pemoline Injections.
G. Beach and D. P. Kimble (1967)
Science 155, 698-701
   Abstract »    PDF »
Magnesium Pemoline: Lack of Facilitation in Human Learning, Memory, and Performance Tests.
R. G. Smith (1967)
Science 155, 603-605
   Abstract »    PDF »
Time-Dependent Processes in Memory Storage.
J. L. McGaugh (1966)
Science 153, 1351-1358
   Abstract »    PDF »


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